15-PGDH as A Therapeutic Target for Cholangiocarcinoma
نویسندگان
چکیده
منابع مشابه
miR-21 targets 15-PGDH and promotes cholangiocarcinoma growth.
UNLABELLED miRNAs are a group of small, noncoding RNAs that modulate the translation of genes by binding to specific target sites in the target mRNA. This study investigated the biologic function and molecular mechanism of miR-21 in human cholangiocarcinoma. In situ hybridization analysis of human cholangiocarcinoma specimens showed increased miR-21 in cholangiocarcinoma tissue compared with th...
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BACKGROUND Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are the two most common primary liver cancers, yet there have been no significant advances in effective therapeutics. Mesothelin has been reported as a new therapeutic target in various types of cancer. Here, we investigated the expression of mesothelin in liver cancer and its potential role as a novel therapeutic target for...
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Hui Yang1, Lili Chen2, Yuxin Chen3 and Guangwei Wei4* 1Department of Gastrointestinal Surgery, Shandong Province Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan, 250012, P.R China 2Department of Pathology, Jinan Forth People’s Hospital, 50 Shifan Road, Jinan, 250012, P.R China 3Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jin...
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About 3 decades ago CD6 identified as one of the first antigens expresses on the majority of T cells and a subset of B cells. CD6 regulates cellular adhesion migration across the endothelial and epithelial cells. In recent years researches indicate its role in pathogenesis of autoimmune diseases. Many researches have been done in recent years to block CD6 by CD6 mono clonal antibodies, IOR-T1 a...
متن کاملNAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer.
It has been reported that two inducible prostaglandin synthetic enzymes, cylooxygenase-2 (COX-2) and microsomal PGE synthase, are over-expressed in non-small cell lung cancer (NSCLC). Using quantitative reverse transcription-polymerase chain reaction, we analyzed RNA levels of the key prostaglandin catabolic enzyme, NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH), in 19 pairs of NSC...
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ژورنال
عنوان ژورنال: Pharmaceutica Analytica Acta
سال: 2015
ISSN: 2153-2435
DOI: 10.4172/2153-2435.1000371